ActiMaris AG

Studies

You can request detailed studies and laboratory reports from us upon request.

Published studies with ActiMaris products:

1. ENT Study
   ActiMaris clinical ENT study on inflammatory skin and mucosal conditions
2. Acne Study
   Clinical observational study on a sea salt-oxygen complex for local application
3. JWC Study: Prontosan vs ActiMaris
   A clinical evaluation of the efficacy and safety of singlet oxygen in cleansing and disinfecting stagnating wounds
4. Witten Study (in vitro study with 6 HOCl/NaOCl wound products)
   Safety and efficacy profiles of different commercial sodium hypochlorite/hypochlorous acid solutions (NaClO/HOCl): antimicrobial efficacy, cytotoxic impact, and physicochemical parameters in vitro
5. Antimicrobial in vivo Study
   Use of wet-to-moist cleansing with different irrigation solutions to reduce bacterial bioburden in chronic wounds
6. Interesting Findings
   Retrospective study survey on modern HOCl / NaOCl wound irrigation solutions in daily wound care practice
7. New Perspective on an Old Natural Concept
   The secret of the Rosetta Stone, REDOX code, and the role of HOCl/NaOCl hybrid solutions (data analysis) in local therapy of chronic wounds
8. Advantages of Negative Pressure Wound Therapy
   Advantages of negative pressure wound therapy with instillation of super oxidized solution and dwell time in diabetic foot syndrome: a rare case report
9. Antimicrobial Efficacy of Five Wound Irrigation Solutions in the Periprosthetic Joint Infection Microenvironment In Vitro and Ex Vivo
10. Modern wound irrigation solutions on the test bench for practice
    A follow-up in vitro study cross-checking existing in vivo data
11. Critically colonized and locally infected wounds (pro care 9-2015 – G. Kammerlander et al.)
12. Wet/Dry Phase 3.0 (clinicum 6-24 – G. Kammerlander et al.)
13. Modern wound irrigation solutions and silver-containing wound products (pro care 5-2020 – G. Kammerlander et al.)
14. Evaluation of the biofilm-killing effect of various antimicrobial solutions (IIS La Fe, Palex 2025)
15. Does the In Vitro Efficacy Promise Correlate with In Vivo Reality and Clinical Effectiveness in Local Wound Treatment with Antimicrobials? (Abu Dhabi Wound Care Conference 4-2025; a review)
16. Antimicrobial efficacy, cytotoxic impact, and physicochemical parameters of HOCl/NaOCl solution used in wound care: an in vitro study (Int. Wound Journal 2018)
17. Effect of Actimaris forte in an in vitro infection model with S. aureus MRSA on synthetic bone fragments (Rome, 2025)
18. Testing the Microbicidal Efficacy and Safety of ActiMaris (National Institute of Public Health (SZÚ), Prague CZ)
19. Confarma Laboratory Test

Currently, four clinical randomized comparative studies with ActiMaris products are ongoing:

1. Bioflush – Removal of intestinal biofilms to reduce IBS symptoms, an exploratory randomized, controlled, observer-subject-blinded study.
   (ActiMaris SENSITIVE wound irrigation solution vs. Placebo)
2. Comparative study of two local therapy concepts
   (ActiMaris SENSITIVE wound irrigation solution and ActiMaris woundgel vs. Microdacyn wound irrigation solution and Microdacyn Gel)
3. Utilizzo di antisettici per il trattamento della gengivite in età pediatrica.
   (ActiMaris FORTE vs. clorexidina 0.12%)
4. ActiMaris effectiveness in the evaluation of the ability of sodium hypochlorite solution in bacterial eradication from conteminated cancellus bone.
   Preliminary results show a dramatical reduction in bacterial growth on culture bases, even for the short period of contact between ActiMaris FORTE wound irrigation solution and cancellous bone (with an almost complete absence of growth after 4 minutes.)
5. John Hopkins Evidence-Based Practice Model for Nursing and Healthgare Professionals.
   What is the best practice in improving the healing process of wound among ICU adults and geriatric patients?
   Decubitus / Pressure injury therapy concept with ActiMaris products at the geriatric clinic.
   Emirates Health Services (EHS Dubai) / EBP team. Maitha Ebrahim / Dr. Rania & Ms. Hanane Egli (ActiMaris representative) Goal comletion date: 2nd to 3rd Quarter 2023

Studies planned with ActiMaris products:

1. The USE of ActiMaris Solution and Gel in the Prevention and Treatment of Periodontal Diseases
2. The USE of ActiMaris Solution and Gel during Endodontic Treatment
3. ActiMaris Solution vs. Comparator(s) for Thoracic and Abdominal Lavage during/after Surgery for differnt Infaction Processes and Peritonitis.

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